![]() In this concern, this minireview mainly focused on the developments of Quinoline synthesis via radical reactions. ![]() ![]() Recently, radical insertion or catalyzed reactions have emerged as a powerful and efficient tool to construct heterocycles with high atom efficiency and step economy. The classical methods including, Skraup, Friedlander, Doebner-von-Miller, Conrad-Limpach, Pfitzinger quinoline synthesis, and so forth, these are the well-known methods to construct principal quinoline scaffold with several advantages and limitations. Over the past few decades, numerous reports have been documented in the synthesis of quinolines. Quinoline is considered one of the most ubiquitous heterocycles due to its engaging biological activities and synthetic utility over organic transformations.
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